Effectiveness of recombinant Escherichia coli on the production of (R)-(+)-perillyl alcohol.

ABSTRACT:

Background

(R)-(+)-perillyl alcohol is a naturally oxygenated monoterpene widely used as the natural flavor additives, insecticides, jet fuels and anti-cancer therapies. It was also readily available monoterpene precursors. However, this natural product is present at low concentrations from plant sources which are not economically viable. Therefore, alternative microbial production methods are rapidly emerging as an attractive alternative to make (R)-(+)-perillyl alcohol production more sustainable and environmentally friendly.

Results

We engineered Escherichia coli to possess a heterologous mevalonate (MVA) pathway, including limonene synthase, P-cymene monoxygenase hydroxylase and P-cymene monoxygenase reductase for the production of (R)-(+)-perillyl alcohol. The concentra

SUBMITTER: Sun C 

PROVIDER: S-EPMC7791655 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature