Preclinical efficacy of stem cell therapy for skin flap: a systematic review and meta-analysis.

ABSTRACT:

Background

A skin flap is one of the most critical surgical techniques for the restoration of cutaneous defects. However, the distal necrosis of the skin flap severely restricts the clinical application of flap surgery. As there is no consensus on the treatment methods to prevent distal necrosis of skin flaps, more effective and feasible interventions to prevent skin flaps from necrosis are urgently needed. Stem therapy as a potential method to improve the survival rate of skin flaps is receiving increasing attention.

Methods

This review followed the recommendations from the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statements. Twenty studies with 500 animals were included by searching Web of Science, EMBASE, PubMed, and Cochrane Library dat

SUBMITTER: Li Y 

PROVIDER: S-EPMC7791712 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature