Pulmonary restriction predicts long-term pulmonary impairment in people with HIV and tuberculosis.

ABSTRACT:

Background

While tuberculosis is considered a risk factor for chronic obstructive pulmonary disease, a restrictive pattern of pulmonary impairment may actually be more common among tuberculosis survivors. We aimed to determine the nature of pulmonary impairment before and after treatment among people with HIV and tuberculosis and identify risk factors for long-term impairment.

Methods

In this prospective cohort study conducted in South Africa, we enrolled adults newly diagnosed with HIV and tuberculosis who were initiating antiretroviral therapy and tuberculosis treatment. We measured lung function and symptoms at baseline, 6, and 12 months. We compared participants with and without pulmonary impairment and constructed logistic regression models to identify characteristics a

SUBMITTER: Auld SC 

PROVIDER: S-EPMC7791797 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature