Glucocorticoid guides mobilization of bone marrow stem/progenitor cells via FPR and CXCR4 coupling.

ABSTRACT:

Background

Our previous studies have proved the efficient exogenous repairing responses via bone marrow stem and progenitor cells (BMSPCs). However, the trafficking of endogenous bone marrow stem and progenitor cells to and from the bone marrow (BM) is a highly regulated process that remains to be elucidated. We aimed to study the relative importance of the hypothalamic-pituitary-adrenal (HPA) axis in the glucocorticoid-induced BMSPC mobilization.

Methods

The circulating mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) were examined in Crh (+/+, -/-) mice after running stress or glucocorticoid mini-infusion. The MSCs and EPCs were investigated ex vivo after treatment with glucocorticoid and glucocorticoid receptor (GR) antagonist, RU486. The expression o

SUBMITTER: Gao W 

PROVIDER: S-EPMC7791823 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature