Identification of thrombomodulin as a dynamic monitoring biomarker for deep venous thrombosis evolution.

ABSTRACT: It has been demonstrated that thrombomodulin (TM) serves an important role in the formation of deep venous thrombosis (DVT) and is regarded to be a marker that can be used to measure vascular endothelial cell damage. However, how TM levels change during DVT evolution has not yet been well understood. The current study aimed to investigate the dynamic changes of TM during the evolution of DVT and explore the possible mechanisms behind these. A total of 48 patients newly diagnosed with DVT and 23 matched healthy controls were enrolled in the present study, and their plasma TM levels were examined and compared. In addition, a DVT model was established using Sprague-Dawley rats via the 'stenosis' method. The thrombi size, histopathologic changes and expression of TM and NF-κB in plasma and ven

SUBMITTER: Cheng X 

PROVIDER: S-EPMC7791923 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature