Temporal changes in DNA methylation and RNA expression in a small song bird: within- and between-tissue comparisons.

ABSTRACT:

Background

DNA methylation is likely a key mechanism regulating changes in gene transcription in traits that show temporal fluctuations in response to environmental conditions. To understand the transcriptional role of DNA methylation we need simultaneous within-individual assessment of methylation changes and gene expression changes over time. Within-individual repeated sampling of tissues, which are essential for trait expression is, however, unfeasible (e.g. specific brain regions, liver and ovary for reproductive timing). Here, we explore to what extend between-individual changes in DNA methylation in a tissue accessible for repeated sampling (red blood cells (RBCs)) reflect such patterns in a tissue unavailable for repeated sampling (liver) and how these DNA methylation patter

SUBMITTER: Lindner M 

PROVIDER: S-EPMC7792223 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature