Time-Dependent Cardiovascular Treatment Benefit Model for Lipid-Lowering Therapies.

ABSTRACT: Background With the availability of new lipid-lowering therapy options, there is a need to compare the expected clinical benefit of different treatment strategies in different patient populations and over various time frames. We aimed to develop a time-dependent model from published randomized controlled trials summarizing the relationship between low-density lipoprotein cholesterol lowering and cardiovascular risk reduction and to apply the model to investigate the effect of treatment scenarios over time. Methods and Results A cardiovascular treatment benefit model was specified with parameters as time since treatment initiation, magnitude of low-density lipoprotein cholesterol reduction, and additional patient characteristics. The model was estimated from randomized controlled trial data

SUBMITTER: Khan I 

PROVIDER: S-EPMC7792260 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature