Rapid Precision Functional Mapping of Individuals Using Multi-Echo fMRI.

ABSTRACT: Resting-state functional magnetic resonance imaging (fMRI) is widely used in cognitive and clinical neuroscience, but long-duration scans are currently needed to reliably characterize individual differences in functional connectivity (FC) and brain network topology. In this report, we demonstrate that multi-echo fMRI can improve the reliability of FC-based measurements. In four densely sampled individual humans, just 10 min of multi-echo data yielded better test-retest reliability than 30 min of single-echo data in independent datasets. This effect is pronounced in clinically important brain regions, including the subgenual cingulate, basal ganglia, and cerebellum, and is linked to three biophysical signal mechanisms (thermal noise, regional variability in the rate of T₂^∗</

SUBMITTER: Lynch CJ 

PROVIDER: S-EPMC7792478 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature