Network Meta-Analysis of Novel Glucose-Lowering Drugs on Risk of Acute Kidney Injury.

ABSTRACT:

Background and objectives

Little is known about the comparative effects of dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 receptor agonists (GLP-1RAs), or sodium glucose cotransporter-2 (SGLT2) inhibitors on risk of AKI. This study aimed to compare the effects of these three novel classes of glucose-lowering drugs on AKI risk in patients with or without type 2 diabetes, by network meta-analysis of event-driven cardiovascular or kidney outcome trials.

Design, setting, participants, & measurements

We systematically searched electronic databases up to September 2020, and included 20 event-driven cardiovascular or kidney outcome trials (18 trials included patients with type 2 diabetes only, and two trials included patients with or without type 2 diabetes). A

SUBMITTER: Zhao M 

PROVIDER: S-EPMC7792639 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature