FOXE1 Gene Dosage Affects Thyroid Cancer Histology and Differentiation In Vivo.

ABSTRACT: The transcription factor Forkhead box E1 (FOXE1) is a key player in thyroid development and function and has been identified by genome-wide association studies as a susceptibility gene for papillary thyroid cancer. Several cancer-associated polymorphisms fall into gene regulatory regions and are likely to affect FOXE1 expression levels. However, the possibility that changes in FOXE1 expression modulate thyroid cancer development has not been investigated. Here, we describe the effects of FOXE1 gene dosage reduction on cancer phenotype in vivo. Mice heterozygous for FOXE1 null allele (FOXE1^+/-) were crossed with a BRAF^V600E-inducible cancer model to develop thyroid cancer in either a FOXE1^+/+ or FOXE

SUBMITTER: Credendino SC 

PROVIDER: S-EPMC7792778 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature