Pathogenetic Role and Clinical Implications of Regulatory RNAs in Biliary Tract Cancer.

ABSTRACT: Biliary tract cancer (BTC) is characterised by poor prognosis and low overall survival in patients. This is generally due to minimal understanding of its pathogenesis, late diagnosis and limited therapeutics in preventing or treating BTC patients. Non-coding RNA (ncRNA) are small RNAs (mRNA) that are not translated to proteins. ncRNAs were considered to be of no importance in the genome, but recent studies have shown they play essential roles in biology and oncology such as transcriptional repression and degradation, thus regulating mRNA transcriptomes. This has led to investigations into the role of ncRNAs in the pathogenesis of BTC, and their clinical implications. In this review, the mechanisms of action of ncRNA are discussed and the role of microRNAs in BTC is summarised. The scope of

SUBMITTER: Ofoeyeno N 

PROVIDER: S-EPMC7792779 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature