Ontology highlight
ABSTRACT:
SUBMITTER: Curry AM
PROVIDER: S-EPMC7792806 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Curry Alyson M AM Barton Elizabeth E Kang Wenjia W Mongeluzi Daniel V DV Cen Yana Y
Molecules (Basel, Switzerland) 20201222 1
NAD<sup>+</sup> (nicotinamide adenine dinucleotide)-dependent protein deacylases, namely, the sirtuins, are important cell adaptor proteins that alter cell physiology in response to low calorie conditions. They are thought to mediate the beneficial effects of calorie restriction to extend longevity and improve health profiles. Novel chemical probes are highly desired for a better understanding of sirtuin's roles in various biological processes. We developed a group of remarkably simple activity- ...[more]