Time-course analysis of the effect of embedded metal on skeletal muscle gene expression.

ABSTRACT: As a consequence of military operations, many veterans suffer from penetrating wounds and long-term retention of military-grade heavy metal fragments. Fragments vary in size and location, and complete surgical removal may not be feasible or beneficial in all cases. Increasing evidence suggests retention of heavy metal fragments may have serious biological implications, including increased risks for malignant transformation. Previous studies assessed the tumorigenic effects of metal alloys in rats, demonstrating combinations of metals are sufficient to induce tumor formation after prolonged retention in skeletal muscle tissue. In this study, we analyzed transcriptional changes in skeletal muscle tissue in response to eight different military-relevant pure metals over 12 mo. We found that mo

SUBMITTER: Wen Y 

PROVIDER: S-EPMC7792808 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature