Sulforhodamine B and exogenous surfactant effects on alveolar surface tension under acute respiratory distress syndrome conditions.

ABSTRACT: In the acute respiratory distress syndrome (ARDS), alveolar surface tension, T, may be elevated. Elevated T should increase ventilation-induced lung injury. Exogenous surfactant therapy, intended to lower T, has not reduced mortality. Sulforhodamine B (SRB) might, alternatively, be used to lower T. We test whether substances suspected of elevating T in ARDS raise T in the lungs and test the abilities of exogenous surfactant and SRB to reduce T. In isolated rat lungs, we micropuncture a surface alveolus and instill a solution of a purported T-raising substance: control saline, cell debris, secretory phospholipase A₂ (sPLA₂), acid, or mucins. We test each substance alone; with albumin, to model proteinaceous edema

SUBMITTER: Nguyen TL 

PROVIDER: S-EPMC7792849 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature