Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study.

ABSTRACT:

Background

Few studies have examined the associations of trimethylamine-N-oxide (TMAO) and its precursors (choline, betaine, dimethylglycine, and L-carnitine) with the risk of atrial fibrillation (AF) and heart failure (HF). This study sought to investigate these associations.

Methods

Prospective associations of these metabolites with incident AF and HF were examined among participants at high cardiovascular risk in the PREDIMED study (PREvención con DIeta MEDiterránea) after follow-up for about 10 years. Two nested case-control studies were conducted, including 509 AF incident cases matched to 618 controls and 326 HF incident cases matched to 426 controls. Plasma levels of TMAO and its precursors were semi-quantitatively profiled with liquid chromatography tandem mass spect

SUBMITTER: Papandreou C 

PROVIDER: S-EPMC7793226 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature