Residual Cardiovascular Risk at Low LDL: Remnants, Lipoprotein(a), and Inflammation.

ABSTRACT:

Background

Current guidelines target low-density lipoprotein cholesterol (LDL-C) concentrations to reduce atherosclerotic cardiovascular disease (ASCVD) risk, and yet clinical trials demonstrate persistent residual ASCVD risk despite aggressive LDL-C lowering.

Content

Non-LDL-C lipid parameters, most notably triglycerides, triglyceride-rich lipoproteins (TGRLs), and lipoprotein(a), and C-reactive protein as a measure of inflammation are increasingly recognized as associated with residual risk after LDL-C lowering. Eicosapentaenoic acid in statin-treated patients with high triglycerides reduced both triglycerides and ASCVD events. Reducing TGRLs is believed to have beneficial effects on inflammation and atherosclerosis. High lipoprotein(a) concentrations increase ASCVD risk e

SUBMITTER: Hoogeveen RC 

PROVIDER: S-EPMC7793228 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature