Long-term experimental evolution of HIV-1 reveals effects of environment and mutational history.

ABSTRACT: An often-returning question for not only HIV-1, but also other organisms, is how predictable evolutionary paths are. The environment, mutational history, and random processes can all impact the exact evolutionary paths, but to which extent these factors contribute to the evolutionary dynamics of a particular system is an open question. Especially in a virus like HIV-1, with a large mutation rate and large population sizes, evolution is expected to be highly predictable if the impact of environment and history is low, and evolution is not neutral. We investigated the effect of environment and mutational history by analyzing sequences from a long-term evolution experiment, in which HIV-1 was passaged on 2 different cell types in 8 independent evolutionary lines and 8 derived lines, 4 of whic

SUBMITTER: Bons E 

PROVIDER: S-EPMC7793244 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature