GATA factor-regulated solute carrier ensemble reveals a nucleoside transporter-dependent differentiation mechanism.

ABSTRACT: Developmental-regulatory networks often include large gene families encoding mechanistically-related proteins like G-protein-coupled receptors, zinc finger transcription factors and solute carrier (SLC) transporters. In principle, a common mechanism may confer expression of multiple members integral to a developmental process, or diverse mechanisms may be deployed. Using genetic complementation and enhancer-mutant systems, we analyzed the 456 member SLC family that establishes the small molecule constitution of cells. This analysis identified SLC gene cohorts regulated by GATA1 and/or GATA2 during erythroid differentiation. As >50 SLC genes shared GATA factor regulation, a common mechanism established multiple members of this family. These genes included Slc29a1 encoding an equilibrative n

SUBMITTER: Zwifelhofer NM 

PROVIDER: S-EPMC7793295 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature