Precision Medicine in Kidney Transplantation: Just Hype or a Realistic Hope?

ABSTRACT: Desirable outcomes including rejection- and infection-free kidney transplantation are not guaranteed despite current strategies for immunosuppression and using prophylactic antimicrobial medications. Graft survival depends on factors beyond human leukocyte antigen matching such as the level of immunosuppression, infections, and management of other comorbidities. Risk stratification of transplant patients based on predisposing genetic modifiers and applying precision pharmacotherapy may help improving the transplant outcomes. Unlike certain fields such as oncology in which consistent attempts are being carried out to move away from the "error and trial approach," transplant medicine is lagging behind in implementing personalized immunosuppressive therapy. The need for maintaining a precario

SUBMITTER: Nobakht E 

PROVIDER: S-EPMC7793397 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature