Recognition of Bimolecular Logic Operation Pattern Based on a Solid-State Nanopore.

ABSTRACT: Nanopores have a unique advantage for detecting biomolecules in a label-free fashion, such as DNA that can be synthesized into specific structures to perform computations. This method has been considered for the detection of diseased molecules. Here, we propose a novel marker molecule detection method based on DNA logic gate by deciphering a variable DNA tetrahedron structure using a nanopore. We designed two types of probes containing a tetrahedron and a single-strand DNA tail which paired with different parts of the target molecule. In the presence of the target, the two probes formed a double tetrahedron structure. As translocation of the single and the double tetrahedron structures under bias voltage produced different blockage signals, the events could be assigned into four different

SUBMITTER: Yan H 

PROVIDER: S-EPMC7793508 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature