Selection of Effective Therapies Using Three-Dimensional in vitro Modeling of Chondrosarcoma.

ABSTRACT: Purpose: Chondrosarcomas are a group of cartilaginous malignant neoplasms characterized by the deposition of chondrogenic extracellular matrix. Surgical resection is currently the only curative treatment option, due to their high resistance to conventional chemotherapy and radiotherapy. Novel therapeutic treatment options may improve outcome. Predominantly used cell line monolayer in vitro models lack in vivo complexity, such as the presence of extracellular matrix, and differing oxygen access. Hence, we aimed to improve pre-clinical chondrosarcoma research by developing an alginate-based 3D cell culture model. Method: An alginate scaffold was applied to generate spheroids of three chondrosarcoma cell lines (CH2879, JJ012, SW1353). Morphological, histological an

SUBMITTER: Palubeckaite I 

PROVIDER: S-EPMC7793672 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature