Risk Factors for Adverse Neurodevelopment in Transient or Persistent Congenital Hyperinsulinism.

ABSTRACT:

Objective

Aim was to identify hypotheses why adverse neurodevelopment still occurs in children with transient or persistent hyperinsulinism despite improvements in long-term treatment options during the last decades.

Material and methods

A retrospective review of 87 children with transient (n=37) or persistent congenital hyperinsulinism (CHI) (n=50) was conducted at the University Children's Hospital Duesseldorf, Germany. Possible risk factors for neurodevelopmental sequelae due to hypoglycemia were analyzed with a focus on the first days after onset of disease.

Results

Median age at follow-up was 7 years (IQR 8). Adverse neurodevelopmental outcome was seen in 34.5% (n=30) of all CHI patients. Fifteen had mildly abnormal neurodevelopment and 15 had a severe hypoglycem

SUBMITTER: Roeper M 

PROVIDER: S-EPMC7793856 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature