The Role of TIM-3 in Hepatocellular Carcinoma: A Promising Target for Immunotherapy?

ABSTRACT: One of the most common tumors in the world is hepatocellular carcinoma (HCC), and its mortality rates are still on the rise, so addressing it is considered an important challenge for universal health. Despite the various treatments that have been developed over the past decades, the prognosis for advanced liver cancer is still poor. Recently, tumor immunotherapy has opened new opportunities for suppression of tumor progression, recurrence, and metastasis. Besides this, investigation into this malignancy due to high immune checkpoint expression and the change of immunometabolic programming in immune cells and tumor cells is highly considered. Because anti-cytotoxic T lymphocyte-associated protein (CTLA)-4 antibodies and anti-programmed cell death protein (PD)-1 antibodies have shown therape

SUBMITTER: Ganjalikhani Hakemi M 

PROVIDER: S-EPMC7793963 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature