The axonal sorting activity of pseudorabies virus Us9 protein depends on the state of neuronal maturation.

ABSTRACT: Alpha-herpesviruses establish a life-long infection in the nervous system of the affected host; while this infection is restricted to peripheral neurons in a healthy host, the reactivated virus can spread within the neuronal circuitry, such as to the brain, in compromised individuals and lead to adverse health outcomes. Pseudorabies virus (PRV), an alpha-herpesvirus, requires the viral protein Us9 to sort virus particles into axons and facilitate neuronal spread. Us9 sorts virus particles by mediating the interaction of virus particles with neuronal transport machinery. Here, we report that Us9-mediated regulation of axonal sorting also depends on the state of neuronal maturation. Specifically, the development of dendrites and axons is accompanied with proteomic changes that influence neur

SUBMITTER: Tanneti NS 

PROVIDER: S-EPMC7794026 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature