Genetic polymorphism of the prostasin gene in hypertensive pregnant Pakistani females.

ABSTRACT:

Objective

The study was performed to investigate the association of hypertension in pregnancy with prostasin gene polymorphism in Pakistani females.

Methods

This case-control study was performed at University of Karachi, Pakistan from April 2018 to May 2019. A total of 160 females, including 90 hypertensives and 70 healthy pregnant females, were recruited by purposive sampling after obtaining informed written consent. Genotyping was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).

Results

The frequencies of the TC and CC genotypes were higher in hypertensive pregnant females compared to healthy controls. A significant difference was evident for CC (P=0.012) genotype; however, no significant difference was observed for T

SUBMITTER: Ejaz S 

PROVIDER: S-EPMC7794134 | biostudies-literature | 2021 Jan-Feb

REPOSITORIES: biostudies-literature