L-Selectin expression is associated with inflammatory microenvironment and favourable prognosis in breast cancer.

ABSTRACT: L-selectin is a cell adhesion molecule that plays an important role in modulating immune cell trafficking. The expression of L-selectin has been found to be upregulated in several human cancers. However, the association of L-selectin expression with the immune profile and its prognostic value in breast cancer has not been explored in detail. We utilized TCGA and Oncomine datasets to compare SELL (L-selectin gene) expression between tumor and normal breast tissues. The association of SELL expression with its promoter DNA methylation and infiltrating immune cells was evaluated by using Wanderer, TIMER, and CIBERSORT tools. Single cell RNA sequencing data was utilised to determine the cell specific expression of L-selectin in breast cancer. Furthermore, the relationship between

SUBMITTER: Kumari S 

PROVIDER: S-EPMC7794266 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature