The Relationship Between Macula Retinal Ganglion Cell Density and Visual Function in the Nonhuman Primate.

ABSTRACT:

Purpose

Loss of ganglion cell inner plexiform layer (GCIPL) and visual sensitivity in the macula region are known to occur at all stages of glaucoma. While both are dependent on the underlying retinal ganglion cells (RGCs), the relationship between structure and function is modest. We hypothesize that the imprecise relationship is due to a lack of direct correspondence between in vivo measures and RGC counts, as well as the relatively large stimulus size used by standard perimetry, which exceeds spatial summation.

Methods

The relationship between optical coherence tomography (OCT)-derived GCIPL thickness and corresponding inner cell density from retinal flat mounts was determined for four nonhuman primates with varying stages of neuropathy. Normative data for 10-2 threshold

SUBMITTER: Antwi-Boasiako K 

PROVIDER: S-EPMC7794274 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature