Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange.

ABSTRACT: Dynamic combinatorial chemistry applied to biological environments requires the exchange chemistry of choice to take place under physiological conditions. Thiol-disulfide exchange, one of the most popular dynamic combinatorial chemistries, usually needs long equilibration times to reach the required equilibrium composition. Here we report selenocystine as a catalyst mimicking Nature's strategy to accelerate thiol-disulfide exchange at physiological pH and low temperatures. Selenocystine is able to accelerate slow thiol-disulfide systems and to promote the correct folding of an scrambled RNase A enzyme, thus broadening the practical range of pH conditions for oxidative folding. Additionally, dynamic combinatorial chemistry target-driven self-assembly processes are tested using spermine, spe

SUBMITTER: Canal-Martin A 

PROVIDER: S-EPMC7794297 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature