Resilin-mimetics as a smart biomaterial platform for biomedical applications.

ABSTRACT: Intrinsically disordered proteins have dramatically changed the structure-function paradigm of proteins in the 21^st century. Resilin is a native elastic insect protein, which features intrinsically disordered structure, unusual multi-stimuli responsiveness and outstanding resilience. Advances in computational techniques, polypeptide synthesis methods and modular protein engineering routines have led to the development of novel resilin-like polypeptides (RLPs) including modular RLPs, expanding their applications in tissue engineering, drug delivery, bioimaging, biosensors, catalysis and bioelectronics. However, how the responsive behaviour of RLPs is encoded in the amino acid sequence level remains elusive. This review summarises the milestones of RLPs, and discusses the developm

SUBMITTER: Balu R 

PROVIDER: S-EPMC7794388 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature