Effects of aerobic exercise training on muscle plasticity in a mouse model of cervical spinal cord injury.

ABSTRACT: Cervical spinal cord injury (SCI) results in permanent life-altering motor and respiratory deficits. Other than mechanical ventilation for respiratory insufficiency secondary to cervical SCI, effective treatments are lacking and the development of animal models to explore new therapeutic strategies are needed. The aim of this work was to demonstrate the feasibility of using a mouse model of partial cervical spinal hemisection at the second cervical metameric segment (C2) to investigate the impact of 6 weeks training on forced exercise wheel system on locomotor/respiratory plasticity muscles. To measure run capacity locomotor and respiratory functions, incremental exercise tests and diaphragmatic electromyography were done. In addition, muscle fiber type composition and capillary distributi

SUBMITTER: Jesus I 

PROVIDER: S-EPMC7794462 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature