The causal role of circulating vitamin D concentrations in human complex traits and diseases: a large-scale Mendelian randomization study.

ABSTRACT: Vitamin D has been associated with a variety of human complex traits and diseases in observational studies, but a causal relationship remains unclear. To examine a putative causal effect of vitamin D across phenotypic domains and disease categories, we conducted Mendelian randomization (MR) analyses using genetic instruments associated with circulating 25-hydroxyvitamin D [25(OH)D] concentrations. We leveraged genome-wide significant 25(OH)D-associated SNPs (N = 138) from a meta-analysis combining a vitamin D GWAS conducted in 401,460 white British UK Biobank (UKBB) participants and an independent vitamin D GWAS including 42,274 samples of European ancestry, and examined 190 large-scale health-related GWAS spanning a broad spectrum of complex traits, diseases and biomarkers. We applied mul

SUBMITTER: Jiang X 

PROVIDER: S-EPMC7794542 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature