Prognostic gene expression signatures of breast cancer are lacking a sensible biological meaning.

ABSTRACT: The identification of prognostic biomarkers for predicting cancer progression is an important problem for two reasons. First, such biomarkers find practical application in a clinical context for the treatment of patients. Second, interrogation of the biomarkers themselves is assumed to lead to novel insights of disease mechanisms and the underlying molecular processes that cause the pathological behavior. For breast cancer, many signatures based on gene expression values have been reported to be associated with overall survival. Consequently, such signatures have been used for suggesting biological explanations of breast cancer and drug mechanisms. In this paper, we demonstrate for a large number of breast cancer signatures that such an implication is not justified. Our approach eliminates

SUBMITTER: Manjang K 

PROVIDER: S-EPMC7794581 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature