Analysis of human mitochondrial genome co-occurrence networks of Asian population at varying altitudes.

ABSTRACT: Networks have been established as an extremely powerful framework to understand and predict the behavior of many large-scale complex systems. We studied network motifs, the basic structural elements of networks, to describe the possible role of co-occurrence of genomic variations behind high altitude adaptation in the Asian human population. Mitochondrial DNA (mtDNA) variations have been acclaimed as one of the key players in understanding the biological mechanisms behind adaptation to extreme conditions. To explore the cumulative effects of variations in the mitochondrial genome with the variation in the altitude, we investigated human mt-DNA sequences from the NCBI database at different altitudes under the co-occurrence motifs framework. Analysis of the co-occurrence motifs using similar

SUBMITTER: Verma RK 

PROVIDER: S-EPMC7794584 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature