Alveolar compartmentalization of inflammatory and immune cell biomarkers in pneumonia-related ARDS.

ABSTRACT:

Background

Biomarkers of disease severity might help individualizing the management of patients with the acute respiratory distress syndrome (ARDS). Whether the alveolar compartmentalization of biomarkers has a clinical significance in patients with pneumonia-related ARDS is unknown. This study aimed at assessing the interrelation of ARDS/sepsis biomarkers in the alveolar and blood compartments and explored their association with clinical outcomes.

Methods

Immunocompetent patients with pneumonia-related ARDS admitted between 2014 and 2018 were included in a prospective monocentric study. Bronchoalveolar lavage (BAL) fluid and blood samples were obtained within 48 h of admission. Twenty-two biomarkers were quantified in BAL fluid and serum. HLA-DR⁺ monocytes and CD

SUBMITTER: Bendib I 

PROVIDER: S-EPMC7794625 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature