LSD1 is an environmental stress-sensitive negative modulator of the glutamatergic synapse.

ABSTRACT: Along with neuronal mechanisms devoted to memory consolidation -including long term potentiation of synaptic strength as prominent electrophysiological correlate, and inherent dendritic spines stabilization as structural counterpart- negative control of memory formation and synaptic plasticity has been described at the molecular and behavioral level. Within this work, we report a role for the epigenetic corepressor Lysine Specific Demethylase 1 (LSD1) as a negative neuroplastic factor whose stress-enhanced activity may participate in coping with adverse experiences. Constitutively increasing LSD1 activity via knocking out its dominant negative splicing isoform neuroLSD1 (neuroLSD1^KO mice), we observed extensive structural, functional and behavioral signs of excitatory decay, inc

SUBMITTER: Longaretti A 

PROVIDER: S-EPMC7794663 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature