Assessment of Advanced Glycation End Products and Receptors and the Risk of Dementia.

ABSTRACT:

Importance

Advanced glycation end products (AGEs) and their receptor (RAGE) are implicated in the pathophysiological processes of dementia and potentially underlie the association of diabetes with neurodegeneration. However, longitudinal studies examining this association are lacking.

Objective

To determine whether markers of the AGE-RAGE system are associated with prevalent and incident dementia and with cognition.

Design, setting, and participants

In this population-based cohort study including participants from the prospective Rotterdam Study, extracellular newly identified RAGE binding protein (EN-RAGE) and soluble RAGE (S-RAGE) were measured in plasma collected between 1997 and 1999 in a random selection of participants, and additionally in participants with prev

SUBMITTER: Chen J 

PROVIDER: S-EPMC7794665 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature