Pharmacological and Parenteral Nutrition-Based Interventions in Microvillus Inclusion Disease.

ABSTRACT: Microvillus inclusion disease (MVID) is a rare inherited and invariably fatal enteropathy, characterized by severe intractable secretory diarrhea and nutrient malabsorption. No cure exists, and patients typically die during infancy because of treatment-related complications. The need for alternative treatment strategies is evident. Several pharmacological interventions with variable successes have been tried and reported for individual patients as part of their clinical care. Unfortunately, these interventions and their outcomes have remained hidden in case reports and have not been reviewed. Further, recent advances regarding MVID pathogenesis have shed new light on the outcomes of these pharmacological interventions and offer suggestions for future clinical research and trials. Hence, an

SUBMITTER: Leng C 

PROVIDER: S-EPMC7794843 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature