Imaging Biomarkers in Animal Models of Drug-Induced Lung Injury: A Systematic Review.

ABSTRACT: For drug-induced interstitial lung disease (DIILD) translational imaging biomarkers are needed to improve detection and management of lung injury and drug-toxicity. Literature was reviewed on animal models in which in vivo imaging was used to detect and assess lung lesions that resembled pathological changes found in DIILD, such as inflammation and fibrosis. A systematic search was carried out using three databases with key words "Animal models", "Imaging", "Lung disease", and "Drugs". A total of 5749 articles were found, and, based on inclusion criteria, 284 papers were selected for final data extraction, resulting in 182 out of the 284 papers, based on eligibility. Twelve different animal species occurred and nine various imaging modalities were used, with two-thirds of the studies being

SUBMITTER: Mahmutovic Persson I 

PROVIDER: S-EPMC7795017 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature