Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update.

ABSTRACT: An optimal host-microbiota interaction in the human vagina governs the reproductive health status of a woman. The marked depletion in the beneficial Lactobacillus sp. increases the risk of infection with sexually transmitted pathogens, resulting in gynaecological issues. Vaginal infections that are becoming increasingly prevalent, especially among women of reproductive age, require an effective concentration of antimicrobial drugs at the infectious sites for complete disease eradication. Thus, topical treatment is recommended as it allows direct therapeutic action, reduced drug doses and side effects, and self-insertion. However, the alterations in the physiological conditions of the vagina affect the effectiveness of vaginal drug delivery considerably. Conventional vaginal dosage forms ar

SUBMITTER: Pandey M 

PROVIDER: S-EPMC7795176 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature