How the AHR Became Important in Cancer: The Role of Chronically Active AHR in Cancer Aggression.

ABSTRACT: For decades, the aryl hydrocarbon receptor (AHR) was studied for its role in environmental chemical toxicity i.e., as a quirk of nature and a mediator of unintended consequences of human pollution. During that period, it was not certain that the AHR had a "normal" physiological function. However, the ongoing accumulation of data from an ever-expanding variety of studies on cancer, cancer immunity, autoimmunity, organ development, and other areas bears witness to a staggering array of AHR-controlled normal and pathological activities. The objective of this review is to discuss how the AHR has gone from a likely contributor to genotoxic environmental carcinogen-induced cancer to a master regulator of malignant cell progression and cancer aggression. Particular focus is placed on the associat

SUBMITTER: Wang Z 

PROVIDER: S-EPMC7795223 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature