Structural Aspects and Prediction of Calmodulin-Binding Proteins.

ABSTRACT: Calmodulin (CaM) is an important intracellular protein that binds Ca2+ and functions as a critical second messenger involved in numerous biological activities through extensive interactions with proteins and peptides. CaM's ability to adapt to binding targets with different structures is related to the flexible central helix separating the N- and C-terminal lobes, which allows for conformational changes between extended and collapsed forms of the protein. CaM-binding targets are most often identified using prediction algorithms that utilize sequence and structural data to predict regions of peptides and proteins that can interact with CaM. In this review, we provide an overview of different CaM-binding proteins, the motifs through which they interact with CaM, and shared properties that ma

SUBMITTER: Andrews C 

PROVIDER: S-EPMC7795363 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature