Review of Experimental Studies to Improve Radiotherapy Response in Bladder Cancer: Comments and Perspectives.

ABSTRACT: Bladder cancer is among the top ten most common cancer types in the world. Around 25% of all cases are muscle-invasive bladder cancer, for which the gold standard treatment in the absence of metastasis is the cystectomy. In recent years, trimodality treatment associating maximal transurethral resection and radiotherapy combined with concurrent chemotherapy is increasingly used as an organ-preserving alternative. However, the use of this treatment is still limited by the lack of biomarkers predicting tumour response and by a lack of targeted radiosensitising drugs that can improve the therapeutic index, especially by limiting side effects such as bladder fibrosis. In order to improve the bladder-preserving treatment, experimental studies addressing these main issues ought to be considered (

SUBMITTER: Silina L 

PROVIDER: S-EPMC7795454 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature