Model Amphipathic Peptide Coupled with Tacrine to Improve Its Antiproliferative Activity.

ABSTRACT: Drug repurposing and drug combination are two strategies that have been widely used to overcome the traditional development of new anticancer drugs. Several FDA-approved drugs for other indications have been tested and have demonstrated beneficial anticancer effects. In this connection, our research group recently reported that Tacrine, used to treat Alzheimer's Disease, inhibits the growth of breast cancer MCF-7 cells both alone and in combination with a reference drug. In this view, we have now coupled Tacrine with the model amphipathic cell-penetrating peptide (CPP) MAP, to ascertain whether coupling of the CPP might enhance the drug's antiproliferative properties. To this end, we synthesized MAP through solid-phase peptide synthesis, coupled it with Tacrine, and made a comparative eval

SUBMITTER: Silva S 

PROVIDER: S-EPMC7795729 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature