Tedizolid-Cyclodextrin System as Delayed-Release Drug Delivery with Antibacterial Activity.

ABSTRACT: Progressive increase in bacterial resistance has caused an urgent need to introduce new antibiotics, one of them being oxazolidinones with their representative tedizolid. Despite the broad spectrum of activity of the parent tedizolid, it is characterized by low water solubility, which limits its use. The combination of the active molecule with a multifunctional excipient, which is cyclodextrins, allows preservation of its pharmacological activity and modification of its physicochemical properties. Therefore, the aim of the study was to change the dissolution rate and permeability through the model membrane of tedizolid by formation of solid dispersions with a cyclodextrin. The research included identification of tedizolid-hydroxypropyl-β-cyclodextrin (tedizolid/HP-β-CD) inclusion complex b

SUBMITTER: Paczkowska-Walendowska M 

PROVIDER: S-EPMC7795824 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature