QSAR Models for Human Carcinogenicity: An Assessment Based on Oral and Inhalation Slope Factors.

ABSTRACT: Carcinogenicity is a crucial endpoint for the safety assessment of chemicals and products. During the last few decades, the development of quantitative structure-activity relationship ((Q)SAR) models has gained importance for regulatory use, in combination with in vitro testing or expert-based reasoning. Several classification models can now predict both human and rat carcinogenicity, but there are few models to quantitatively assess carcinogenicity in humans. To our knowledge, slope factor (SF), a parameter describing carcinogenicity potential used especially for human risk assessment of contaminated sites, has never been modeled for both inhalation and oral exposures. In this study, we developed classification and regression models for inhalation and oral SFs using data from the Risk Ass

SUBMITTER: Toma C 

PROVIDER: S-EPMC7796303 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature