Surgical Treatment of Intrahepatic Cholangiocarcinoma: Current and Emerging Principles.

ABSTRACT: Intrahepatic cholangiocarcinoma (ICC) is a rare, aggressive cancer of the biliary tract. It often presents with locally advanced or metastatic disease, but for patients with early-stage disease, surgical resection with negative margins and portahepatis lymphadenectomy is the standard of care. Recent advancements in ICC include refinement of staging, improvement in liver-directed therapies, clarification of the role of adjuvant therapy based on new randomized controlled trials, and advances in minimally invasive liver surgery. In addition, improvements in neoadjuvant strategies and surgical techniques have enabled expanded surgical indications and reduced surgical morbidity and mortality. However, recurrence rates remain high and more effective systemic therapies are still necessary to impr

SUBMITTER: Beal EW 

PROVIDER: S-EPMC7796337 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature