Equine synovial fluid small non-coding RNA signatures in early osteoarthritis.

ABSTRACT:

Background

Osteoarthritis remains one of the greatest causes of morbidity and mortality in the equine population. The inability to detect pre-clinical changes in osteoarthritis has been a significant impediment to the development of effective therapies against this disease. Synovial fluid represents a potential source of disease-specific small non-coding RNAs (sncRNAs) that could aid in the understanding of the pathogenesis of osteoarthritis. We hypothesised that early stages of osteoarthritis would alter the expression of sncRNAs, facilitating the understanding of the underlying pathogenesis and potentially provide early biomarkers.

Methods

Small RNA sequencing was performed using synovial fluid from the metacarpophalangeal joints of both control and early osteoarthritic ho

SUBMITTER: Castanheira C 

PROVIDER: S-EPMC7796526 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature