Plasma contact factors as novel biomarkers for diagnosing Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is the most common cause of dementia and most of AD patients suffer from vascular abnormalities and neuroinflammation. There is an urgent need to develop novel blood biomarkers capable of diagnosing Alzheimer's disease (AD) at very early stage. This study was performed to find out new accurate plasma diagnostic biomarkers for AD by investigating a direct relationship between plasma contact system and AD.

Methods

A total 101 of human CSF and plasma samples from normal and AD patients were analyzed. The contact factor activities in plasma were measured with the corresponding specific peptide substrates.

Results

The activities of contact factors (FXIIa, FXIa, plasma kallikrein) and FXa clearly increased and statistically correlated as

SUBMITTER: Park JE 

PROVIDER: S-EPMC7796542 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature