Expression and function of Ndel1 during the differentiation of neural stem cells induced by hippocampal exosomesticle.

ABSTRACT:

Background

In the brain of adult mammals, neural stem cells persist in the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus, which are specialized niches with proliferative capacity. Most neural stem cells are in a quiescent state, but in response to extrinsic stimuli, they can exit from quiescence and become reactivated to produce new neurons, so neural stem cells are considered to be a potential source for cell replacement therapy of many nervous system diseases. We characterized the expression of Ndel1 during the differentiation of neural stem cells induced by hippocampus exosomes, and assessed the effect of Ndel1 on neural stem cells differentiation.

Methods

Hippocampal exosomes were isolated and extracted, and co-cultured exosom

SUBMITTER: Li W 

PROVIDER: S-EPMC7796549 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature