Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction.

ABSTRACT:

Motivation

Drug-induced liver injury (DILI) is one of the primary problems in drug development. Early prediction of DILI can bring a significant reduction in the cost of clinical trials. In this work we examined whether occurrence of DILI can be predicted using gene expression profile in cancer cell lines and chemical properties of drugs.

Methods

We used gene expression profiles from 13 human cell lines, as well as molecular properties of drugs to build Machine Learning models of DILI. To this end, we have used a robust cross-validated protocol based on feature selection and Random Forest algorithm. In this protocol we first identify the most informative variables and then use them to build predictive models. The models are first built using data from single cell lines, and

SUBMITTER: Lesinski W 

PROVIDER: S-EPMC7796564 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature